Akihiro Nishiguchi

Principal Researcher, Research Center for Macromolecules and Biomaterials, National Institute for Materials Science*Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: Development of in vivo vascularization technology by controlling liquid-liquid- phase separation

Keyword

Summary: Cell transplantation has been used as a treatment for ischemic diseases. However, the low cellular attachment rate of cell transplantation alone has been an issue. Inspired by the phenomenon of liquid-liquid phase separation observed in cells, this study aims to develop an injectable gel with a porous structure and apply it to the technology to construct vascular structures in vivo. This material, which is injectable and has a porous structure, is expected to improve the efficiency of transplanted cells' viability and restore ischemic conditions through cell infiltration, sustained release of angiogenic factors, and supply of oxygen and nutrients.

Message

This research is to develop new biomaterials for regenerative medicine. We would like to express our gratitude for the research grant despite the challenging subject. We will devote ourselves to the development of materials with unprecedented originality.

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