Chie Aoki-Utsubo

Graduate School of Health Sciences, Kobe UniversityAssistant Professor*Profile is at the time of the award.

2018Inamori Research GrantsBiology & Life sciences

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Research topics: Identification of new antiviral agents against hepatitis viruses from polyphenolic compounds derived from Indonesian medicinal plants

Keyword

Summary: Hepatitis B viruses (HBVs) and hepatitis C viruses (HCVs) are internationally rampant infectious diseases that can cause hepatic cirrhosis and hepatic cancer. The antiviral therapy, which is currently used to treat HBV, inhibits the growth of viruses to mitigate hepatitis, but it is hard to completely get rid of viruses from the body. Meanwhile, direct acting antivirals (DAAs), which are often chosen for treatment of hepatitis C patients, are not without problems, such as high cost and drug resistance. This being the case, development of a new, effective, lower-cost hepatitis virus therapeutic agent is in demand. Our research team has identified vaticanol B, a new HCV infection inhibitor, in Dryobalanops aromatica, a plant in the Dipterocarpaceae family found in Indonesia. This proposed research is intended to elucidate the mechanism of viral infection inhibition by vaticanol B and search for a more powerful related substance from plants in Indonesia, thus identifying new substances derived from natural sources that control HBV and HCV infection.

Message from recipient

I feel truly honored to be selected for the Inamori Research Grants Program from among so many outstanding research projects. I am hoping to discover useful antihepatitis virus materials from natural resources in Indonesia, which boasts rich biodiversity, so I can contribute to the development of novel remedies.

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