Arisa Hirano

Assistant Professor, Institute of Medicine, University of Tsukuba*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Elucidation of the neuronal mechanism regulating body temperature rhythm.

Keyword

Summary: The circadian clock generates various physiological rhythms, such as the sleep-wake cycle, body temperature, and metabolism, regulating biological conditions and behaviors in accordance with the time of day. For example, in humans, body temperature is higher during the daytime when activity levels are high, but it drops sharply at bedtime. This decrease is believed to be essential for initiating deep sleep. However, with aging, the daily fluctuation in body temperature becomes smaller, and the decline in body temperature at bedtime slows down, which has been associated with an increased prevalence of sleep disorders in older people. In this research project, I aim to elucidate how the circadian clock regulates body temperature rhythms at the neural level and to explore their physiological significance.

Comment

The circadian clock system, which is universally shared among living organisms, possesses key characteristics such as "robustness," "flexibility," and "temperature compensation," making it a scientifically fascinating research topic. On the other hand, disruptions in circadian rhythms can lead to a decline in quality of life and an increased risk of various diseases. As modern society makes it easier for daily rhythms to become irregular, this topic has also gained medical attention. By understanding the clock system that regulates circadian rhythms and finding ways to manipulate it, I hope to contribute to improving people's health.

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