Ryusuke Hatae

Assistant Professor,Graduate School of Medical Sciences, Kyushu University*Profile is at the time of the award.

2020Inamori Research GrantsBiology & Life sciences

Research topics: Immune-metabolome study of the mechanism of resistance to immune checkpoint inhibitors in cancer patients with brain metastasis

Keyword

Summary: Immunotherapy, especially PD-1 antibody-based immunotherapy has revolutionized the treatment of various cancers. However, results from clinical trials indicate that PD-1 antibodies are less effective against brain tumors. In this study, we will analyze the plasma metabolites and the energy metabolism of lymphocytes from patients with brain metastases who were treated with PD-1 antibodies. The aim of this study is to elucidate the mechanisms underlying the unresponsiveness of brain tumors to immunotherapy on the basis of immune metabolism.

Message

It has been a great honor to receive the Inamori Research Grant. I hope to develop this research further and to develop new treatments for the patients with brain tumors.

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