Hisaaki Hirose

Program-Specific Associate Professor, Institute for Chemical Research, Kyoto University*Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

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Research topics: Elucidation of the cell selectivity mechanism of the antibody cytosolic delivery peptide

Keyword

Summary: Antibody drugs are promising therapeutics for many diseases, but their targets have been limited to extracellular molecules due to their low permeability through cell membranes. The development of simple and feasible methods to deliver antibodies into cells will lead to an expansion of drug targets.
The L17E peptide can easily deliver macromolecules, including antibodies, into living cells. However, the details of how the peptide interacts with the cell membrane and delivers macromolecules remain unclear. I will elucidate the molecular basis of L17E-based intracellular delivery to develop a more effective method for intracellular delivery of antibodies.

Comment

I am grateful to the Inamori Foundation and the reviewers for this prestigious research grant. I will elucidate and understand the mechanisms of cellular functions and designed molecules so that my research can bridge between basic and applied research as well as between chemistry and cell biology.

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