Hideaki Kato

Associate Professor,Graduate School of Arts and Sciences, The University of Tokyo*Profile is at the time of the award.

2020Inamori Research GrantsBiology & Life sciences

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Research topics: Structural and functional analysis of intermediate states during the formation of promiscuous-GPCR-G protein complex

Keyword

Summary: I have used cryo-electron microscopy to determine the structure of the neurotensin receptor (NTSR1), a promiscuous GPCR (i.e., a GPCR capable of activating multiple G proteins), and its intermediate complex formation with Gi. Based on various previous studies, I thought that the observed intermediates might be common to promiscuous GPCRs in general, and in the present study, I analyze the structure of promiscuous GPCRs and G-protein complexes other than NTSR1. In this way, I aim to elucidate the universal rules underlying the complex formation process.

Message

I am very honored to be recognized as an original study. I hope I can continue to make progress so as not to disappoint you.

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