Shunsuke Kon

Junior Associate Professor,Research Institute for Biomedical Sciences, Tokyo University of Science*Profile is at the time of the award.

2020Inamori Research GrantsBiology & Life sciences

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Research topics: Study of an anti-tumorigenic function exerted by cell competition regulated by autophagy

Keyword

Carcinogenesis

Summary: Recent research results have shown that when a small number of cancer mutant cells are produced in the epithelial cell layer, a phenomenon called "cell competition" occurs between normal cells and cancer mutant cells to compete for survival, and as a result, cancer mutant cells are eliminated from the epithelial layer. We have recently found that the non-degradable function of the autophagosome positively regulates cell competition. This project aims to understand the antitumor function of autophagy in the very early stages of cancer by elucidating the molecular status and cellular physiological significance of autophagy.

Message

Autophagy research in Japan is leading the world, mainly in cell biology research, as recognized by Dr. Yoshinori Osumi's Nobel Prize in Physiology or Medicine in 2016. However, research on its physiological and pathological significance lags behind that of other countries. In this grant, I will elucidate the cancer control mechanism of autophagy in the very early stages of carcinogenesis and work hard to develop innovative cancer therapies that utilize autophagy.

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