Michihito Kono

Specially Appointed Assistant Professor, Hokkaido University Hospital, Hokkaido University *Profile is at the time of the award.

2021Inamori Research GrantsBiology & Life sciences

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Research topics: Cell metabolism as a therapeutic target in systemic lupus erythematosus

Keyword

Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that involves the kidney, the central nervous systems, and the skin. We have previously shown that IL-17-producing CD4+ T cells (Th17) utilize glycolysis and glutaminolysis more than regulatory T cells (Tregs), and inhibition of these metabolic pathways could be therapeutic targets of SLE. The aim of this study is to clarify how T cell metabolism is crucial in the pathogenesis of SLE and to find the new therapeutic targets of this disease.

Comment

I would like to express my sincere gratitude to the Inamori Foundation for the research grant. I am a rheumatologist, and I will also conduct translational research with the dream of developing new treatments for autoimmune diseases.

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