Kazunori Kume

Associate Professor, Graduate School of Integrated Sciences for Life, Hiroshima University *Profile is at the time of the award.

2021Inamori Research GrantsBiology & Life sciences

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Research topics: Elucidation of the mechanism that creates direction to membrane transport between nucleus and endoplasmic reticulum

Keyword

Summary: Eukaryotic cells have multiple organelles that are covered with membranes. The nucleus is one of the most important organelles because it houses and protects genomic DNA and forms higher-order structures for gene expression. In most eukaryotes, the size of the nucleus is strictly controlled in order for the genome to function. It is known that the size of the nucleus changes in proportion to the cell size, but the control mechanism remains unclear and is one of the major mysteries in biology. In this study, we will attempt to unveil this mystery by elucidating the mechanism that generates the directionality of membrane transport between the two organelles focusing on the membrane transport between the nucleus and the endoplasmic reticulum in the regulation of nuclear size.

Comment

I want to develop important, original, in-depth research! I will do my best!

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