Takahiro Masuda

Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyushu University *Profile is at the time of the award.

2021Inamori Research GrantsBiology & Life sciences

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Research topics: Understanding of homeostatic brain development and CNS pathology through a comprehensive analysis of CNS-associated macrophages

Keyword

Summary: The central nervous system, including the brain and spinal cord, is organized by the complex and highly dynamic interaction of a wide variety of cells, such as neurons, glial cells, and vascular cells. In the process of formation and maintenance, microglia, known as brain macrophages, perform various functions in the brain parenchyma, such as removal of dead cells, promotion of neuronal differentiation, and synaptic pruning. On the other hand, there are different types of macrophages (CAMs: CNS-associated macrophages) from microglia in the central and peripheral border regions such as perivascular and meninges. However, their physiological and pathophysiological roles, as well as fundamental information such as distribution, dynamics, and gene expression profiles from early development to the adult, have not yet been clarified. In this project, we aim to create a basic database for the analysis of CAMs, including their development, distribution, dynamics, gene expression profiles, and diversity from early development to adult, using the latest technologies such as one-cell omics analysis, fate mapping, in vivo imaging, and computer remodeling. Furthermore, we aim to gain a comprehensive understanding of the developmental functions and significance of CAMs by elucidating the functions of CAMs, which have not been elucidated to date, as well as the mechanisms of central nervous system diseases triggered by their abnormal functions.

Comment

I want to clarify the significance of CAMs distributed in the border region between the central and peripheral nervous systems!

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