Yuichiro Mishima

Faculty of Lifesciences, Kyoto Sangyo UniversityAssociate Professor*Profile is at the time of the award.

2019Inamori Research GrantsBiology & Life sciences

website researchmap

Research topics: A comprehensive study about the mRNA stability code hidden in the genetic code

Keyword

Summary: Recently, there has been growing recognition that mRNA stability control involves a control hierarchy essential for higher-order life phenomena. Our original research project using early embryos of zebrafish as a model discovered that the composition of codons (genetic codes) determines mRNA stability in the early embryo. This finding implies that not only amino-acid sequencing but also information that concerns the fate of mRNA itself is coded in the open reading frame (ORF). Little has been known about how this alternative source of information hidden in codons is retrieved and what physiological roles it plays. This proposed research is aimed at reaching a comprehensive understanding of the mRNA stability code through the application and development of the RNA experimental system that we have built with zebrafish by: 1) deciphering the mRNA stability code on the molecular level; 2) clarifying the mechanism of perceiving the mRNA stability code; and 3) elucidating the role that the mRNA stability code plays in ontogeny.

Message from recipient

Our research started from a simple question about the mechanism of life. We feel deeply grateful that this basic research of ours has been recognized. With the Inamori Foundation generously supporting our research, we will do our best to yield deeply meaningful results.

Find other recipients

Biology & Life sciences

Hideaki Kato

The University of Tokyo

Ryusuke Hatae

Kyushu University

Satoshi Miura

Information Science

Nobuhiko Yokoshi

Keio University

Kyogo Kobayashi

Kyushu University

Yuta Hiraike

The University of Tokyo

Akiko Kanehara

Masayuki Morita

Ehime University

Wakana Tanaka

The University of Tokyo

Shintaro Munemasa

Okayama University

Toshiki Sawada

Material Science

Noriyoshi Usui

Osaka University

Tomohiro Otsuka

Tomomi Koshiyama

Ritsumeikan University

Aiko Sada

Okayama University

Atsushi Fujimura

Okayama University

Yuki Honda

Material Science

Masahiro Morimoto

Rie Wakabayashi

Kyushu University

Kenji Ikeda

Tokyo Medical and Dental University

Kenta Maruyama

Aichi Medical University

Taichi Itoh

Biology & Life sciences

Taichi Noda

The University of Tokyo

Yasuo Oguri

Biology & Life sciences Life Science

Daisuke Ino

Osaka University

Kaori Sako

Koji Atarashi

Masaki Uchida

Masaru Hojo

Kwansei Gakuin University

Tsuyoshi Waku

Doshisha University

Takumi Ogawa

Osaka Prefecture University

Hirofumi Toda

University of Tsukuba

Hiroyoshi Y. Tanaka

Okayama University

Hidehisa Kawashima

University of Tsukuba

Akihiko Mougi

Shimane University

Azusa Kondoh

Biology & Life sciences Pharmacy

Yusuke Kobayashi

Mizuki Watanabe

Hokkaido University

Keita Takahashi

Takashi Shimada

Biology & Life sciences

Tomohisa Hosokawa

Nagoya University

Kazuhiko Yamamuro

Minako Ito

Yoshiaki Abe

University of Tsukuba

Masashi Mamada

Material Science

Kenta Hirami

Akihiro Funamizu

Information Science

Toshiyuki Kowada

Biology & Life sciences Life Science

Shunsuke Kon

Tokyo University of Science

Hiroshi Suzuki

Nagoya University

InaRIS Fellow

Takaaki Ozawa

Osaka University

Shintaro Yamaguchi

Jun-ichi Sakamaki

Juntendo University

Tomomi Tsunematsu

Hokkaido University

Kenichi Watanabe

Kunihiko Morihiro

The University of Tokyo

Takanori Wakatake

Nara Institute of Science and Technology

So Nagaoka

Biology & Life sciences Life Science

Tsuyoshi Terakawa

Kyoto University

Chie Aoki-Utsubo

Kobe University

Mizuki Endo

Toyoaki Natsume

Research Organization of Information and Systems

Shohei Yamamoto

Tokyo Medical and Dental University

Nami Minato

Yoshiyuki Manabe

Tokai University

Hirohisa Ohno

Kyoto University

Yuma Takahashi

Nara Institute of Science and Technology

Shun Shibata

Tohoku University

Chikara Abe

Gifu University

Tsuyoshi Hirashima

Kyoto University

Ayuko Hoshino

The University of Tokyo

InaRIS Fellow

Yuhei Chadani

Okayama University

Kazuki Ide

June-Sik Kim

RIKEN

Hironori Takeda

Hiroshima University

Takumi Suzuki

Ibaraki University

Akari Fujimoto

Takayuki Kuraishi

Kanazawa University

Dana Ulanova

Kochi University

Kazuya Matsuo

Gosuke Hayashi

Biology & Life sciences Pharmacy

Masanori Nomoto

University of Toyama

Kazutoshi Iijima

Yokohama National University

Hiroshi Masai

Material Science

Seiya Takayanagi

Kiyoharu Fukushima

Kyoto University

Tomoko Okamoto

Hidenori Okamura

Tohoku University

Koichi Murata

Kyoto University

Yu Fukasawa

Tohoku University

Susumu Jitsuki

Biology & Life sciences Life Science

Keiichiro Suzuki

Osaka University

Takuma Kokusho

Tomoya Yamaguchi

Kumamoto University

Masashi Kanayama

Tokyo Medical and Dental University

Masahiko Saito

Material Science

Ayaka Ito

Yohei Hayashi

Tohoku University

Takashi Iwasaki

Tottori University

Shohei Nosaki

University of Tsukuba

Yuji Sakai

Tokushima University

Kenichi Kimura

University of Tokyo

Hidenori Nishio

Nagoya City University

Ayako Gotoh

Konan University

Hiroshi Miyanishi

University of Miyazaki

Takashi Tanaka

Atsushi Saito

Sapporo Medical University

Kazutoshi Kasho

Biology & Life sciences Life Science

Michihito Kono

Daisuke Takimoto

Material Science

Masayuki Tera

Tokyo University of Agriculture and Technology

Kenji Osabe

Tokyo Institute of Technology

Asano Ishikawa

Research Organization of Information and Systems

Masayuki Tsukasaki

The University of Tokyo

Saori Morino-Koga

The University of Tokyo

Atsushi Anzai

Biology & Life sciences Medicine

Kotaro Mizuta

Kyoto University

Takuya Motooka

Tomonori Nakamura

Kyoto University

Akihiro Goto

Biology & Life sciences Life Science

Tomomi Wakabayashi

Osaka University

Tomoyuki Furuta

Okayama University

Hiroshi Nishimasu

The University of Tokyo

InaRIS Fellow

Takuya Matsumoto

Osaka Prefecture University

Junichi Kikuta

University of Tsukuba

Shunsuke Tagami

RIKEN

Shizue Ohsawa

Nagoya University

Satoshi Minami

Osaka University

Kyoko Miura

Kumamoto University

Katsuma Hayashi

Kyoto University

Tomonori Matsumoto

Biology & Life sciences Medicine

Akihiro Nishiguchi

National Institute for Materials Science

Teruhiko Imamura

Masayuki Sakamoto

Kumamoto University

Toshiro Moroishi

Makoto Kobayashi

Misuzu Hashimoto

Gifu University

Yuto Takenaka

Ritsumeikan University

Hidefumi Shinohara

Nagoya University

Chihiro Maeda

Material Science

Hideaki Morishita

Biology & Life sciences Life Science

Takashi Tsuchimatsu

Chiba University

Taro Fuchikawa

Osaka City University

Yukiko Kamiya

Kazunori Kume

Akiko Ogawa

Biology & Life sciences Life Science

Yoshifumi Yamaguchi

Hokkaido University

InaRIS Fellow

Satoshi Iwakami

Kyoto University

Takeshi Kawabe

Biology & Life sciences Medicine

Kuniyasu Saitoh

Kozue Shiomi

Biology & Life sciences

Nobuharu Suzuki

Tokyo Medical and Dental University

Mitsuaki Kashiwagi

Biology & Life sciences Life Science

Masato Yamamichi

Research Organization of Information and Systems

Ritsuko Morita

Biology & Life sciences Life Science

Yusaku Iwasaki

Jumpei Taguchi

The University of Tokyo

Yuka Iwasaki

RIKEN

Yukiko Kimura

National Institutes of Natural Sciences

Katsuyoshi Takaoka

Miharu Maeda

Biology & Life sciences Life Science

Yosuke Togashi

Biology & Life sciences Medicine

Kunio Kondoh

Mitsuru Tsuge

Okayama University

Yusuke Kimata

Biology & Life sciences Life Science

Miyako Shiraishi

Osaka University

Hitoshi Miyakawa

Utsunomiya University

Yoshihiro Sakita

Takayuki Suzuki

Nagoya University

Seiji Takashima

Shinshu University

Daisuke Ono

Biology & Life sciences Life Science

Miu Tamamitsu

The University of Tokyo

Tetsuya Kadonosono

Tokyo Institute of Technology

Takahiro Masuda

Yoshihiro Ujihara

Nagoya Institute of Technology

Ryo Fujimoto

Kobe University

Masafumi Kodama

Biology & Life sciences

Hiroshi Nomoto

Hisaaki Hirose

Osaka University

Takashi Fukaya

The University of Tokyo

Masakazu Hirota

Shu Nakao

Ritsumeikan University