Yuichiro Mishima

Faculty of Lifesciences, Kyoto Sangyo UniversityAssociate Professor*Profile is at the time of the award.

2019Inamori Research GrantsBiology & Life sciences

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Research topics: A comprehensive study about the mRNA stability code hidden in the genetic code

Keyword

Summary: Recently, there has been growing recognition that mRNA stability control involves a control hierarchy essential for higher-order life phenomena. Our original research project using early embryos of zebrafish as a model discovered that the composition of codons (genetic codes) determines mRNA stability in the early embryo. This finding implies that not only amino-acid sequencing but also information that concerns the fate of mRNA itself is coded in the open reading frame (ORF). Little has been known about how this alternative source of information hidden in codons is retrieved and what physiological roles it plays. This proposed research is aimed at reaching a comprehensive understanding of the mRNA stability code through the application and development of the RNA experimental system that we have built with zebrafish by: 1) deciphering the mRNA stability code on the molecular level; 2) clarifying the mechanism of perceiving the mRNA stability code; and 3) elucidating the role that the mRNA stability code plays in ontogeny.

Message from recipient

Our research started from a simple question about the mechanism of life. We feel deeply grateful that this basic research of ours has been recognized. With the Inamori Foundation generously supporting our research, we will do our best to yield deeply meaningful results.

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