Shiho Makino

Research Associate, Institute for Quantitatve Biosciences, The University of Tokyo*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Spatiotemporal regulation of selective RNA degradation in early embryogenesis

Keyword

Summary: Autophagy is the major intracellular degradation pathway by which cellular constituents are delivered to and degraded in the vacuole/lysosome. Despite many studies on protein and organelle degradation by autophagy, RNA degradation by autophagy remains poorly understood. Previously, we revealed that autophagy preferentially delivers a subset of mRNA species to the vacuole, where they are subsequently degraded by vacuolar ribonuclease in yeast. However, RNA degradation by autophagy in multicellular organisms and its physiological role remain unclear.
In this project, I aim to investigate the selectivity of RNA degraded by autophagy and its biological significance during early embryogenesis.

Comment

I would like to understand the physiological role of autophagy during early embryonic development from the viewpoint of RNA degradation.

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