Takahito Iga

Project Assistant Professor, School of Medicine, Keio University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

Research topics: Unraveling the Mechanisms Behind Age-Related Delayed Fracture Healing

Keyword

Summary: One of the factors contributing to delayed fracture healing in the elderly is thought to be vascular aging. In young mice, new blood vessels are induced at the fracture site, promoting fracture healing, whereas in aged mice, this vascular formation is reduced. However, we have confirmed that modulating specific vascular regulatory mechanisms enhances angiogenesis and accelerates fracture healing. Furthermore, we have identified a factor involved in promoting healing and are currently evaluating its therapeutic potential through local administration. This study aims to establish new strategies for fracture treatment in the elderly.

Comment

I am very pleased to receive this grant, which will allow me to further advance my research on the mechanisms of delayed fracture healing in the elderly and the development of new treatment strategies. My research focuses on the impact of vascular aging as a factor inhibiting fracture healing and aims to promote healing through vascular regulation. I will continue to dedicate my efforts to ensuring that this research leads to new treatment options for elderly patients with fractures.

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