Mitsuru Tsuge

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversitySenior Assistant Professor*Profile is at the time of the award.

2019Inamori Research GrantsBiology & Life sciences

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Research topics: Brain vascular endothelial dysfunction by high mobility group box 1 in the influenza-associated encephalopathy

Keyword

Summary: I am investigating the way in which the high mobility group box-1 (HMGB-1), a natural immune mediator, is involved in the pathology of influenza-associated encephalopathy. For this purpose, I will construct a blood-brain barrier model using human cerebrovascular endothelial cells and examine the increase of vascular permeability by administering a tracheal epithelial cell supernatant after infection with the influenza virus, the dynamics of intercellular tight junction molecules, and restriction of vascular permeability increase through the use of an HMGB-1 antibody.

Message from recipient

I feel very honored to be a recipient of the Inamori Research Grants. I will press ahead with my developmental research on new forms of treatment to further improve the prognosis of influenza-associated encephalopathy.

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