Tsuyoshi Terakawa

Assistant Professor, Graduate School of Science, Kyoto University*Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: Molecular mechanism of DNA loop formation by transcription factor YY1 explored with DNA curtain single-molecule fluorescence imaging

Keyword

Summary: Although gene expression regulation is the basis of life, its molecular mechanism remains elusive. Gene expression in eukaryotes is controlled by the association and dissociation of DNA sequence regions called enhancers (E) and promoters (P). Recently, it has been revealed that the transcription factor YY1 brings E-P pairs into proximity, but the molecular mechanism is unclear. In this study, we will clarify the molecular mechanism using the single-molecule imaging technique called DNA curtain assay to visualize the dynamics of YY1 forming DNA loops, which bring the E-P pair into proximity.

Message

Elucidating the molecular mechanisms of gene expression is extremely important for deepening the basic understanding of biology. I would like to make the most of the foundation's funding to conduct basic research that will lead to the elucidation of new life phenomena and their applications.

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