Tsuyoshi Waku

Assistant Professor,Faculty of Life and Medical Sciences, Doshisha University*Profile is at the time of the award.

2020Inamori Research GrantsBiology & Life sciences

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Research topics: A novel mechanism of an immune suppression in cancer through an amino-acid uptake competition by a tumorigenic transcription factor NRF3

Keyword

Summary: mTORC1 is a serine/threonine protein kinase which is activated by growth factors and amino acids. mTORC1 activation is essential for not only cancer cell growth, but also the activation of tumor infiltrating T-cells. I have already found that a transcription factor NRF3 promotes cancer development and activates mTORC1 by inducing the expression of several amino acid transporter genes in cancer cells. In this study, I hypothesize that NRF3 exhausts tumor infiltrating T-cells and inhibits cancer immune checkpoint by enhancing an amino acid uptake into cancer cells.

Message

I hope to contribute medical advancements as a basic biologist.

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