Shintaro Yamaguchi

Instructor, School of Medicine, Keio University *Profile is at the time of the award.

2021Inamori Research GrantsBiology & Life sciences

Research topics: Development of a method to augment endogenous incretin secretion by targeting vascular endothelial and intestinal NAD⁺ metabolism

Summary: The purpose of this project is to test the hypothesis that vascular endothelial and intestinal epithelial NAD⁺ biosynthesis regulates endogenous incretin production. In addition, we would investigate if boosting NAD⁺ biosynthesis in vascular endothelial and intestinal epithelial cells augments incretin secretion especially in obesity.

Comment

I believe that our project helps to facilitate translational research to better understand the importance of NAD⁺ metabolism in vascular endothelial and intestinal epithelial cells.

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