Tomoya Yamaguchi

Priority Organization for lnnovation and Excellence, Kumamoto UniversityAssociate Professor*Profile is at the time of the award.

2018Inamori Research GrantsBiology & Life sciences

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Research topics: Role of ROR1 in cell membrane organization and dynamics

Keyword

Summary: We previously identified the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a target for transcriptional activation via the lineage-survival oncogene TTF-1 in lung adenocarcinoma. ROR1 facilitates the interaction of CAVIN1 and CAV1 at the plasma membrane in a kinase activity-independent manner, which in turn sustains caveolae formation and pro-survival signaling towards AKT through multiple RTKs such as EGFR, MET and IGF-IR, via its scaffold function for CAVIN1 and CAV1 in lung cancer. In this project, we focus on the role of ROR1 as a caveolae-regulating molecule for cell membrane organization and dynamics in cancer. The goal of this project is to understand the molecular pathogenesis of human solid tumor, hard-to-cure cancers, especially lung cancer, and then to translate our findings in order to develop novel strategies for better diagnosis, treatment and prevention.

Message from recipient

I feel much obliged to be selected for the 2018 Inamori Research Grants Program. Having just opened a new lab at Kumamoto University, this grant from the Inamori Foundation has greatly propelled my research there. I am hoping to discover a new control mechanism of biomembrane dynamics in cell biology.

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