Yuhei Chadani

Associate Professor, Faculty of Environmental, Life, Natural Science and Technology, Okayama University*Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: Development of a novel toolbox to control genetic information included in the context of amino acid sequences

Keyword

Summary: It has become clear that the genetic information that shapes life is encoded not only in DNA but also in its expression product, proteins (polypeptides). This is due to the ribosome, which translates nucleic acid sequence into amino acid sequence, ignoring the basis of the "central dogma" when synthesizing specific amino acid sequences. In this study, we focused on newly identified translation factors, ABCF proteins, that alleviate such "noncanonical" translations. Through elucidating the molecular details of ABCF-mediated translation regulation, we aim to establish new techniques to control novel genetic information hidden in the context of amino acid sequences.

Message

We are working to decipher and control genetic information encoded in "amino acid" sequences rather than DNA sequences. One of our goals is to create a super Escherichia coli capable of expressing any protein. If you are interested, please contact us!

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