Yuji Sakai

Program-Specific Associate Professor, Institute for Life and Medical Sciences, Kyoto University*Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

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Research topics: Theoretical study of intracellular degradation mechanisms

Keyword

Summary: Intracellular degradation systems are essential for cellular homeostasis. In autophagy, the membrane changes the morphology to form autophagosome, which surround degradation substrates, then fuse with lysosomes for degradation. This means that understanding membrane dynamics is necessary to elucidate the intracellular degradation mechanism. Regulatory molecules have been identified, but how these regulate macroscopic membrane dynamics remains a mystery. In this study, I use mathematical methods to elucidate complex intracellular degradation systems as simple physical phenomena such as membrane deformation and fusion.

Comment

I am very honored to be selected for the Inamori Foundation Research Grant. Encouraged by this grant, I would like to take on new challenges and innovate research on intracellular dynamics from mathematical perspectives.

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